Small interfering RNA library screen identified polo-like kinase-1 (PLK1) as a potential therapeutic target for breast cancer that uniquely eliminates tumor-initiating cells

INTRODUCTION: Triple-negative breast cancer (TNBC) high rate of relapse is thought to be due to the presence of tumor-initiating cells (TICs), molecularly defined as being CD44(high)/CD24(-/low). TICs are resilient to chemotherapy and radiation. However, no currently accepted molecular target exists...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Kaiji, Law, Jennifer H, Fotovati, Abbas, Dunn, Sandra E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496140/
https://www.ncbi.nlm.nih.gov/pubmed/22309939
http://dx.doi.org/10.1186/bcr3107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496140/
https://www.ncbi.nlm.nih.gov/pubmed/22309939
http://dx.doi.org/10.1186/bcr3107

Ejemplares similares