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Small interfering RNA library screen identified polo-like kinase-1 (PLK1) as a potential therapeutic target for breast cancer that uniquely eliminates tumor-initiating cells
INTRODUCTION: Triple-negative breast cancer (TNBC) high rate of relapse is thought to be due to the presence of tumor-initiating cells (TICs), molecularly defined as being CD44(high)/CD24(-/low). TICs are resilient to chemotherapy and radiation. However, no currently accepted molecular target exists...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496140/ https://www.ncbi.nlm.nih.gov/pubmed/22309939 http://dx.doi.org/10.1186/bcr3107 |