APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells

Human APOBEC3 proteins play pivotal roles in intracellular defense against viral infection by catalyzing deamination of cytidine residues, leading to base substitutions in viral DNA. Activation-induced cytidine deaminase (AID), another member of the APOBEC family, is capable of editing immunoglobuli...

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Detalles Bibliográficos
Autores principales: Shinohara, Masanobu, Io, Katsuhiro, Shindo, Keisuke, Matsui, Masashi, Sakamoto, Takashi, Tada, Kohei, Kobayashi, Masayuki, Kadowaki, Norimitsu, Takaori-Kondo, Akifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496164/
https://www.ncbi.nlm.nih.gov/pubmed/23150777
http://dx.doi.org/10.1038/srep00806

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496164/
https://www.ncbi.nlm.nih.gov/pubmed/23150777
http://dx.doi.org/10.1038/srep00806

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