Charge Optimization Theory for Induced-Fit Ligands

The design of ligands with high affinity and specificity remains a fundamental challenge in understanding molecular recognition and developing therapeutic interventions. Charge optimization theory addresses this problem by determining ligand charge distributions that produce the most favorable elect...

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Detalles Bibliográficos
Autores principales: Shen, Yang, Gilson, Michael K., Tidor, Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496346/
https://www.ncbi.nlm.nih.gov/pubmed/23162383
http://dx.doi.org/10.1021/ct200931c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496346/
https://www.ncbi.nlm.nih.gov/pubmed/23162383
http://dx.doi.org/10.1021/ct200931c

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