Potent human uric acid transporter 1 inhibitors: in vitro and in vivo metabolism and pharmacokinetic studies

Human uric acid transporter 1 (hURAT1; SLC22A12) is a very important urate anion exchanger. Elevated urate levels are known to play a pivotal role in cardiovascular diseases, chronic renal disease, diabetes, and hypertension. Therefore, the development of potent uric acid transport inhibitors may le...

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Detalles Bibliográficos
Autores principales: Wempe, Michael F, Lightner, Janet W, Miller, Bettina, Iwen, Timothy J, Rice, Peter J, Wakui, Shin, Anzai, Naohiko, Jutabha, Promsuk, Endou, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496402/
https://www.ncbi.nlm.nih.gov/pubmed/23152669
http://dx.doi.org/10.2147/DDDT.S35805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496402/
https://www.ncbi.nlm.nih.gov/pubmed/23152669
http://dx.doi.org/10.2147/DDDT.S35805

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