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Retinal horizontal cells lacking Rb1 sustain persistent DNA damage and survive as polyploid giant cells
The retinoblastoma tumor susceptibility gene, Rb1, is a key regulator of the cell cycle, and mutations in this gene have been found in many human cancers. Prior studies showed that retina-specific knockout of Rb1 in the mouse results in the formation of abnormally large horizontal cells, but the dev...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The American Society for Cell Biology
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496610/ https://www.ncbi.nlm.nih.gov/pubmed/23015754 http://dx.doi.org/10.1091/mbc.E12-04-0293 |