The Plant-Derived Glucocorticoid Receptor Agonist Endiandrin A Acts as Co-Stimulator of Colonic Epithelial Sodium Channels (ENaC) via SGK-1 and MAPKs

In a search for secondary plant compounds that bind to the glucocorticoid receptor (GR), the cyclobutane lignan endiandrin A was discovered from the rainforest tree Endiandra anthropophagorum Domin. Our present study aims to characterize the effect of endiandrin A on GR-dependent induction of coloni...

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Detalles Bibliográficos
Autores principales: Kuntzsch, Dana, Bergann, Theresa, Dames, Petra, Fromm, Anja, Fromm, Michael, Davis, Rohan A., Melzig, Matthias F., Schulzke, Joerg D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496671/
https://www.ncbi.nlm.nih.gov/pubmed/23152905
http://dx.doi.org/10.1371/journal.pone.0049426

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496671/
https://www.ncbi.nlm.nih.gov/pubmed/23152905
http://dx.doi.org/10.1371/journal.pone.0049426

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