HDAC6 Regulates Epidermal Growth Factor Receptor (EGFR) Endocytic Trafficking and Degradation in Renal Epithelial Cells

We present for the first time that histone deacetylase 6 (HDAC6) regulates EGFR degradation and trafficking along microtubules in Pkd1 mutant renal epithelial cells. HDAC6, the microtubule-associated α-tubulin deacetylase, demonstrates increased expression and activity in Pkd1 mutant mouse embryonic...

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Detalles Bibliográficos
Autores principales: Liu, Wei, Fan, Lucy X., Zhou, Xia, Sweeney, William E., Avner, Ellis D., Li, Xiaogang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496684/
https://www.ncbi.nlm.nih.gov/pubmed/23152903
http://dx.doi.org/10.1371/journal.pone.0049418

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496684/
https://www.ncbi.nlm.nih.gov/pubmed/23152903
http://dx.doi.org/10.1371/journal.pone.0049418

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