HIV-1 Tat Promotes Integrin-Mediated HIV Transmission to Dendritic Cells by Binding Env Spikes and Competes Neutralization by Anti-HIV Antibodies

Use of Env in HIV vaccine development has been disappointing. Here we show that, in the presence of a biologically active Tat subunit vaccine, a trimeric Env protein prevents in monkeys virus spread from the portal of entry to regional lymph nodes. This appears to be due to specific interactions bet...

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Detalles Bibliográficos
Autores principales: Monini, Paolo, Cafaro, Aurelio, Srivastava, Indresh K., Moretti, Sonia, Sharma, Victoria A., Andreini, Claudia, Chiozzini, Chiara, Ferrantelli, Flavia, Cossut, Maria R. Pavone., Tripiciano, Antonella, Nappi, Filomena, Longo, Olimpia, Bellino, Stefania, Picconi, Orietta, Fanales-Belasio, Emanuele, Borsetti, Alessandra, Toschi, Elena, Schiavoni, Ilaria, Bacigalupo, Ilaria, Kan, Elaine, Sernicola, Leonardo, Maggiorella, Maria T., Montin, Katy, Porcu, Marco, Leone, Patrizia, Leone, Pasqualina, Collacchi, Barbara, Palladino, Clelia, Ridolfi, Barbara, Falchi, Mario, Macchia, Iole, Ulmer, Jeffrey B., Buttò, Stefano, Sgadari, Cecilia, Magnani, Mauro, Federico, Maurizio P. M., Titti, Fausto, Banci, Lucia, Dallocchio, Franco, Rappuoli, Rino, Ensoli, Fabrizio, Barnett, Susan W., Garaci, Enrico, Ensoli, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496724/
https://www.ncbi.nlm.nih.gov/pubmed/23152803
http://dx.doi.org/10.1371/journal.pone.0048781

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496724/
https://www.ncbi.nlm.nih.gov/pubmed/23152803
http://dx.doi.org/10.1371/journal.pone.0048781

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