Randomized, Placebo-Controlled Trial of Mipomersen in Patients with Severe Hypercholesterolemia Receiving Maximally Tolerated Lipid-Lowering Therapy

OBJECTIVES: Mipomersen, an antisense oligonucleotide targeting apolipoprotein B synthesis, significantly reduces LDL-C and other atherogenic lipoproteins in familial hypercholesterolemia when added to ongoing maximally tolerated lipid-lowering therapy. Safety and efficacy of mipomersen in patients w...

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Detalles Bibliográficos
Autores principales: McGowan, Mary P., Tardif, Jean-Claude, Ceska, Richard, Burgess, Lesley J., Soran, Handrean, Gouni-Berthold, Ioanna, Wagener, Gilbert, Chasan-Taber, Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496741/
https://www.ncbi.nlm.nih.gov/pubmed/23152839
http://dx.doi.org/10.1371/journal.pone.0049006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3496741/
https://www.ncbi.nlm.nih.gov/pubmed/23152839
http://dx.doi.org/10.1371/journal.pone.0049006

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