Altered DNA Binding and Amplification of Human Breast Cancer Suppressor Gene BRCA1 Induced by a Novel Antitumor Compound, [Ru(η(6)-p-phenylethacrynate)Cl(2)(pta)]

The ruthenium-based complex [Ru(η(6)-p-phenylethacrynate)Cl(2)(pta)] (pta = 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decane), termed ethaRAPTA, is an interesting antitumor compound. The elucidation of the molecular mechanism of drug activity is central to the drug development program. To this end, we...

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Detalles Bibliográficos
Autores principales: Chakree, Korawan, Ovatlarnporn, Chitchamai, Dyson, Paul J., Ratanaphan, Adisorn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497320/
https://www.ncbi.nlm.nih.gov/pubmed/23202946
http://dx.doi.org/10.3390/ijms131013183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497320/
https://www.ncbi.nlm.nih.gov/pubmed/23202946
http://dx.doi.org/10.3390/ijms131013183

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