Production of (R)-3-Quinuclidinol by E. coli Biocatalysts Possessing NADH-Dependent 3-Quinuclidinone Reductase (QNR or bacC) from Microbacterium luteolum and Leifsonia Alcohol Dehydrogenase (LSADH)

We found two NADH-dependent reductases (QNR and bacC) in Microbacterium luteolum JCM 9174 (M. luteolum JCM 9174) that can reduce 3-quinuclidinone to optically pure (R)-(−)-3-quinuclidinol. Alcohol dehydrogenase from Leifsonia sp. (LSADH) was combined with these reductases to regenerate NAD(+) to NAD...

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Detalles Bibliográficos
Autores principales: Isotani, Kentaro, Kurokawa, Junji, Itoh, Nobuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497340/
https://www.ncbi.nlm.nih.gov/pubmed/23202966
http://dx.doi.org/10.3390/ijms131013542

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497340/
https://www.ncbi.nlm.nih.gov/pubmed/23202966
http://dx.doi.org/10.3390/ijms131013542

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