APC15 mediates CDC20 auto-ubiquitylation by APC/C(MCC) and MCC disassembly

The anaphase-promoting complex/cyclosome bound to CDC20 (APC/C(CDC20)) initiates anaphase by ubiquitylating B-type cyclins and securin. During chromosome bi-orientation, CDC20 assembles with MAD2, BUBR1 and BUB3 into a mitotic checkpoint complex (MCC) which inhibits substrate recruitment to the APC/...

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Detalles Bibliográficos
Autores principales: Uzunova, Kristina, Dye, Billy T., Schutz, Hannelore, Ladurner, Rene, Petzold, Georg, Toyoda, Yusuke, Jarvis, Marc A., Brown, Nicholas G., Poser, Ina, Novatchkova, Maria, Mechtler, Karl, Hyman, Anthony A., Stark, Holger, Schulman, Brenda A., Peters, Jan-Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498062/
https://www.ncbi.nlm.nih.gov/pubmed/23007861
http://dx.doi.org/10.1038/nsmb.2412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498062/
https://www.ncbi.nlm.nih.gov/pubmed/23007861
http://dx.doi.org/10.1038/nsmb.2412

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