Cargando…

APC15 mediates CDC20 auto-ubiquitylation by APC/C(MCC) and MCC disassembly

The anaphase-promoting complex/cyclosome bound to CDC20 (APC/C(CDC20)) initiates anaphase by ubiquitylating B-type cyclins and securin. During chromosome bi-orientation, CDC20 assembles with MAD2, BUBR1 and BUB3 into a mitotic checkpoint complex (MCC) which inhibits substrate recruitment to the APC/...

Descripción completa

Detalles Bibliográficos
Autores principales:	Uzunova, Kristina, Dye, Billy T., Schutz, Hannelore, Ladurner, Rene, Petzold, Georg, Toyoda, Yusuke, Jarvis, Marc A., Brown, Nicholas G., Poser, Ina, Novatchkova, Maria, Mechtler, Karl, Hyman, Anthony A., Stark, Holger, Schulman, Brenda A., Peters, Jan-Michael
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498062/ https://www.ncbi.nlm.nih.gov/pubmed/23007861 http://dx.doi.org/10.1038/nsmb.2412

Ejemplares similares

Infrequent alterations of the APC and MCC genes in gastric cancers from British patients.
por: Sud, R., et al.
Publicado: (1996)

Primary Gastric Carcinoma Cells Frequently Lose Heterozygosity at the APC and MCC Genetic Loci
por: Tamura, Gen, et al.
Publicado: (1993)

Fission Yeast Apc15 Stabilizes MCC-Cdc20-APC/C Complexes, Ensuring Efficient Cdc20 Ubiquitination and Checkpoint Arrest
por: May, Karen M., et al.
Publicado: (2017)

TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC
por: Kim, Dong Hyun, et al.
Publicado: (2018)

APC15 drives the turnover of MCC-Cdc20 to make the Spindle Assembly Checkpoint responsive to kinetochore attachment
por: Mansfeld, Jörg, et al.
Publicado: (2011)

Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer.
por: Thompson, A. M., et al.
Publicado: (1993)

MCC Regulator of WNT Signaling Pathway (MCC) Is a Podocyte Essential Gene
por: Song, Hui, et al.
Publicado: (2021)

Living with Merkel Cell Carcinoma (MCC): Development of a Conceptual Model of MCC Based on Patient Experiences
por: Kaufman, Howard L., et al.
Publicado: (2018)

Discovering Dutch Ensembles, MCC9121:

Discovering Dutch Ensembles, MCC9122:

Insights into Anaphase Promoting Complex TPR subdomain assembly from a CDC26–APC6 structure
por: Wang, Jing, et al.
Publicado: (2009)

Frequency of allele loss of DCC, p53, RBI, WT1, NF1, NM23 and APC/MCC in colorectal cancer assayed by fluorescent multiplex polymerase chain reaction.
por: Cawkwell, L., et al.
Publicado: (1994)

ATLAS Pixel MCC on flex with double wirebonds
por: Dobos, Daniel
Publicado: (2005)

Role of MCC/Eisosome in Fungal Lipid Homeostasis
por: Zahumensky, Jakub, et al.
Publicado: (2019)

The Composition and the Structure of MCC/Eisosomes in Neurospora crassa
por: Yang, Qin, et al.
Publicado: (2020)

MCC: the Module Controller Chip for the ATLAS Pixel Detector.
por: Beccherle, R, et al.
Publicado: (2002)

The Module Controller Chip (MCC) of the ATLAS Pixel Detector
por: Darbo, G
Publicado: (1998)

The module controller chip (MCC) of the ATLAS pixel detector
por: Beccherle, R
Publicado: (1998)

Kinetochore-catalyzed MCC formation: A structural perspective
por: Fischer, Elyse S.
Publicado: (2023)

Lactobacillus fermentum MCC2759 and MCC2760 Alleviate Inflammation and Intestinal Function in High-Fat Diet-Fed and Streptozotocin-Induced Diabetic Rats
por: Archer, Ann Catherine, et al.
Publicado: (2021)

Selective Inhibition of Aurora Kinase A by AK-01/LY3295668 Attenuates MCC Tumor Growth by Inducing MCC Cell Cycle Arrest and Apoptosis
por: Das, Bhaba K., et al.
Publicado: (2021)

Sleep and breast and prostate cancer risk in the MCC-Spain study
por: Turner, Michelle C., et al.
Publicado: (2022)

Humidity and measurement of volatile propofol using MCC-IMS (EDMON)
por: Teucke, Tobias, et al.
Publicado: (2022)

Macrophage environment turns otherwise MccJ25-resistant Salmonella into sensitive
por: Pomares, María Fernanda, et al.
Publicado: (2013)

A Comparison of MCC and CEN Error Measures in Multi-Class Prediction
por: Jurman, Giuseppe, et al.
Publicado: (2012)

Mutated in colorectal cancer (MCC) is a novel oncogene in B lymphocytes
por: Edwards, Shanique KE, et al.
Publicado: (2014)

MCC/Eisosomes Regulate Cell Wall Synthesis and Stress Responses in Fungi
por: Foderaro, Jenna E., et al.
Publicado: (2017)

Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Study
por: Gutiérrez-González, Enrique, et al.
Publicado: (2018)

Occupational Exposure to Pesticides and Chronic Lymphocytic Leukaemia in the MCC-Spain Study
por: Benavente, Yolanda, et al.
Publicado: (2020)

MCC: A Tool for Unfolding Colored Petri Nets in PNML Format
por: Dal Zilio, Silvano
Publicado: (2020)

MCC950 closes the active conformation of NLRP3 to an inactive state
por: Tapia-Abellán, Ana, et al.
Publicado: (2019)

The Dietary Inflammatory Index and Chronic Lymphocytic Leukaemia in the MCC Spain Study
por: Flores, José Carlos, et al.
Publicado: (2019)

MCC950 ameliorates ventricular arrhythmia vulnerability induced by heart failure
por: Jiang, Xiaobo, et al.
Publicado: (2022)

Current In Vitro and In Vivo Models to Study MCPyV-Associated MCC
por: Loke, Amanda S. W., et al.
Publicado: (2022)

Association of occupational heat exposure and colorectal cancer in the MCC-Spain study
por: Hinchliffe, Alice, et al.
Publicado: (2023)

Circulating miRNAs signature on breast cancer: the MCC-Spain project
por: Gómez-Acebo, Inés, et al.
Publicado: (2023)

Atomic-Resolution Structures of the APC/C Subunits Apc4 and the Apc5 N-Terminal Domain
por: Cronin, Nora B., et al.
Publicado: (2015)

Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation
por: Ranes, Michael, et al.
Publicado: (2021)

The importance of APC
por: Ablamunits, Vitaly
Publicado: (2005)

Polo meets the APC
por: Wells, William A.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_6sr6rb1h9rn61aqr91jkcvik3c