Exon 1 Disruption Alters Tissue-Specific Expression of Mouse p53 and Results in Selective Development of B Cell Lymphomas

p53 is a tumor suppressor gene mutated in >50% of human cancers, while p53 deficiency in mice results in cancers and accelerated mortality. Thymic T cell lymphoma is the most common malignancy in p53-deficient mice, making it difficult to study the role of p53 in other malignancies. To overcome t...

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Detalles Bibliográficos
Autores principales: Chiang, Y. Jeffrey, Difilippantonio, Michael J., Tessarollo, Lino, Morse, Herbert C., Hodes, Richard J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498120/
https://www.ncbi.nlm.nih.gov/pubmed/23166633
http://dx.doi.org/10.1371/journal.pone.0049305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498120/
https://www.ncbi.nlm.nih.gov/pubmed/23166633
http://dx.doi.org/10.1371/journal.pone.0049305

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