Multiple Novel Alternative Splicing Forms of FBXW7α Have a Translational Modulatory Function and Show Specific Alteration in Human Cancer

FBXW7 acts as a tumor suppressor through ubiquitination and degradation of multiple oncoproteins. Loss of FBXW7 expression, which could be partially attributed by the genomic deletion or mutation of FBXW7 locus, is frequently observed in various human cancers. However, the mechanisms regulating FBXW...

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Detalles Bibliográficos
Autores principales: Liu, Yueyong, Ren, Shancheng, Castellanos-Martin, Andres, Perez-Losada, Jesus, Kwon, Yong-Won, Huang, Yurong, Wang, Zeran, Abad, Mar, Cruz-Hernandez, Juan J., Rodriguez, Cesar A., Sun, Yinghao, Mao, Jian-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498124/
https://www.ncbi.nlm.nih.gov/pubmed/23166673
http://dx.doi.org/10.1371/journal.pone.0049453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498124/
https://www.ncbi.nlm.nih.gov/pubmed/23166673
http://dx.doi.org/10.1371/journal.pone.0049453

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