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An Enhanced Immune Response of Mclk1 (+/−) Mutant Mice Is Associated with Partial Protection from Fibrosis, Cancer and the Development of Biomarkers of Aging

The immune response is essential for survival by destroying microorganisms and pre-cancerous cells. However, inflammation, one aspect of this response, can result in short- and long-term deleterious side-effects. Mclk1 (+/−) mutant mice can be long-lived despite displaying a hair-trigger inflammator...

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Detalles Bibliográficos
Autores principales: Wang, Dantong, Wang, Ying, Argyriou, Catherine, Carrière, Audrey, Malo, Danielle, Hekimi, Siegfried
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498213/
https://www.ncbi.nlm.nih.gov/pubmed/23166727
http://dx.doi.org/10.1371/journal.pone.0049606