Controlled Oxidation of Remote sp(3) C–H Bonds in Artemisinin via P450 Catalysts with Fine-Tuned Regio- and Stereoselectivity

[Image: see text] The selective oxyfunctionalization of isolated sp(3) C–H bonds in complex molecules represents a formidable challenge in organic chemistry. Here, we describe a rational, systematic strategy to expedite the development of P450 oxidation catalysts with refined regio- and stereoselect...

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Detalles Bibliográficos
Autores principales: Zhang, Kaidong, Shafer, Brian M., Demars, Matthew D., Stern, Harry A., Fasan, Rudi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2012
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498520/
https://www.ncbi.nlm.nih.gov/pubmed/23121379
http://dx.doi.org/10.1021/ja3073462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498520/
https://www.ncbi.nlm.nih.gov/pubmed/23121379
http://dx.doi.org/10.1021/ja3073462

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