Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides

Alternative splicing of the pyruvate kinase M gene involves a choice between mutually exclusive exons 9 and 10. Use of exon 10 to generate the M2 isoform is crucial for aerobic glycolysis (the Warburg effect) and tumour growth. We previously demonstrated that splicing enhancer elements that activate...

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Detalles Bibliográficos
Autores principales: Wang, Zhenxun, Jeon, Hyun Yong, Rigo, Frank, Bennett, C. Frank, Krainer, Adrian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498831/
https://www.ncbi.nlm.nih.gov/pubmed/23155487
http://dx.doi.org/10.1098/rsob.120133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498831/
https://www.ncbi.nlm.nih.gov/pubmed/23155487
http://dx.doi.org/10.1098/rsob.120133

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