Cargando…

Manipulation of PK-M mutually exclusive alternative splicing by antisense oligonucleotides

Alternative splicing of the pyruvate kinase M gene involves a choice between mutually exclusive exons 9 and 10. Use of exon 10 to generate the M2 isoform is crucial for aerobic glycolysis (the Warburg effect) and tumour growth. We previously demonstrated that splicing enhancer elements that activate...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Zhenxun, Jeon, Hyun Yong, Rigo, Frank, Bennett, C. Frank, Krainer, Adrian R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society 2012
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3498831/ https://www.ncbi.nlm.nih.gov/pubmed/23155487 http://dx.doi.org/10.1098/rsob.120133

Ejemplares similares

Optimization of Bifunctional Antisense Oligonucleotides for Regulation of Mutually Exclusive Alternative Splicing of PKM Gene
por: Bartyś, Natalia, et al.
Publicado: (2022)

Hybridization-mediated off-target effects of splice-switching antisense oligonucleotides
por: Scharner, Juergen, et al.
Publicado: (2020)

Antisense oligonucleotides correct the familial dysautonomia splicing defect in IKBKAP transgenic mice
por: Sinha, Rahul, et al.
Publicado: (2018)

Antisense-oligonucleotide-directed inhibition of nonsense-mediated mRNA decay
por: Nomakuchi, Tomoki T., et al.
Publicado: (2015)

Comparison of the efficacy of MOE and PMO modifications of systemic antisense oligonucleotides in a severe SMA mouse model
por: Sheng, Lei, et al.
Publicado: (2020)

Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB
por: Khoo, Bernard, et al.
Publicado: (2007)

Antisense-based therapy for the treatment of spinal muscular atrophy
por: Rigo, Frank, et al.
Publicado: (2012)

Enhancement of SMN2 Exon 7 Inclusion by Antisense Oligonucleotides Targeting the Exon
por: Hua, Yimin, et al.
Publicado: (2007)

Nonsense-mediated decay as a terminating mechanism for antisense oligonucleotides
por: Ward, Amanda J., et al.
Publicado: (2014)

Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression
por: Lim, Kian Huat, et al.
Publicado: (2020)

Variable window binding for mutually exclusive alternative splicing
por: Anastassiou, Dimitris, et al.
Publicado: (2006)

Antisense Oligonucleotide Therapeutics for Cystic Fibrosis: Recent Developments and Perspectives
por: Kim, Young Jin, et al.
Publicado: (2023)

Comprehensive analysis of mutually exclusive alternative splicing in C. elegans
por: Kuroyanagi, Hidehito, et al.
Publicado: (2014)

Antisense oligonucleotide therapy for spinocerebellar ataxia type 2
por: Scoles, Daniel R., et al.
Publicado: (2017)

Therapeutic correction of ApoER2 splicing in Alzheimer's disease mice using antisense oligonucleotides
por: Hinrich, Anthony J, et al.
Publicado: (2016)

Programmable mutually exclusive alternative splicing for generating RNA and protein diversity
por: Mathur, Melina, et al.
Publicado: (2019)

Splice-switching antisense oligonucleotides as therapeutic drugs
por: Havens, Mallory A., et al.
Publicado: (2016)

The landscape of human mutually exclusive splicing
por: Hatje, Klas, et al.
Publicado: (2017)

Overcoming imatinib resistance conferred by the BIM deletion polymorphism in chronic myeloid leukemia with splice-switching antisense oligonucleotides
por: Liu, Jun, et al.
Publicado: (2017)

Exon-skipping antisense oligonucleotides for cystic fibrosis therapy
por: Kim, Young Jin, et al.
Publicado: (2022)

Systematic Approach to Developing Splice Modulating Antisense Oligonucleotides
por: Aung-Htut, May T., et al.
Publicado: (2019)

Induction of cryptic pre-mRNA splice-switching by antisense oligonucleotides
por: Ham, Kristin A., et al.
Publicado: (2021)

Delivery of GalNAc-Conjugated Splice-Switching ASOs to Non-hepatic Cells through Ectopic Expression of Asialoglycoprotein Receptor
por: Scharner, Juergen, et al.
Publicado: (2019)

Antisense oligonucleotides as a potential treatment for brain deficits observed in myotonic dystrophy type 1
por: Ait Benichou, Siham, et al.
Publicado: (2022)

Antisense oligonucleotide therapy for KCNT1 encephalopathy
por: Burbano, Lisseth Estefania, et al.
Publicado: (2022)

Fetal antisense oligonucleotide therapy for congenital deafness and vestibular dysfunction
por: Wang, Lingyan, et al.
Publicado: (2020)

Antisense Oligonucleotide-Mediated Removal of the Polyglutamine Repeat in Spinocerebellar Ataxia Type 3 Mice
por: Toonen, Lodewijk J.A., et al.
Publicado: (2017)

Intravitreal Injection of Splice-switching Oligonucleotides to Manipulate Splicing in Retinal Cells
por: Gérard, Xavier, et al.
Publicado: (2015)

Efficient electroporation of neuronal cells using synthetic oligonucleotides: identifying duplex RNA and antisense oligonucleotide activators of human frataxin expression
por: Shen, Xiulong, et al.
Publicado: (2019)

Long-range RNA pairings contribute to mutually exclusive splicing
por: Yue, Yuan, et al.
Publicado: (2016)

Mutually exclusive sense–antisense transcription at FLC facilitates environmentally induced gene repression
por: Rosa, Stefanie, et al.
Publicado: (2016)

Preclinical PK and PD Studies on 2′-O-Methyl-phosphorothioate RNA Antisense Oligonucleotides in the mdx Mouse Model
por: Heemskerk, Hans, et al.
Publicado: (2010)

Rescue of Outer Hair Cells with Antisense Oligonucleotides in Usher Mice Is Dependent on Age of Treatment
por: Ponnath, Abhilash, et al.
Publicado: (2017)

Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice
por: Nazor Friberg, Karah, et al.
Publicado: (2012)

Mechanisms of single-stranded phosphorothioate modified antisense oligonucleotide accumulation in hepatocytes
por: Koller, Erich, et al.
Publicado: (2011)

Reduction of integrin alpha 4 activity through splice modulating antisense oligonucleotides
por: Aung-Htut, May T., et al.
Publicado: (2019)

Antisense Oligonucleotide-Mediated Splice Switching: Potential Therapeutic Approach for Cancer Mitigation
por: Raguraman, Prithi, et al.
Publicado: (2021)

Sarm1 haploinsufficiency or low expression levels after antisense oligonucleotides delay programmed axon degeneration
por: Gould, Stacey Anne, et al.
Publicado: (2021)

Evaluation of potential effects of Plastin 3 overexpression and low-dose SMN-antisense oligonucleotides on putative biomarkers in spinal muscular atrophy mice
por: Strathmann, Eike A., et al.
Publicado: (2018)

Antisense oligonucleotides delivered to the amniotic cavity in utero modulate gene expression in the postnatal mouse
por: Depreux, Frederic F., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_16jtclpio8qq04ueeqjp1p6r6l