The assay design used for measurement of therapeutic antibody concentrations can affect pharmacokinetic parameters: Case studies

To interpret pharmacokinetic (PK) data of biotherapeutics, it is critical to understand which drug species is being measured by the PK assay. For therapeutic antibodies, it is generally accepted that “free” circulating antibodies are the pharmacologically active form needed to determine the PK/ phar...

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Detalles Bibliográficos
Autores principales: Fischer, Saloumeh K., Yang, Jihong, Anand, Banmeet, Cowan, Kyra, Hendricks, Robert, Li, Jing, Nakamura, Gerald, Song, An
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499303/
https://www.ncbi.nlm.nih.gov/pubmed/22820463
http://dx.doi.org/10.4161/mabs.20814

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499303/
https://www.ncbi.nlm.nih.gov/pubmed/22820463
http://dx.doi.org/10.4161/mabs.20814

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