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The assay design used for measurement of therapeutic antibody concentrations can affect pharmacokinetic parameters: Case studies
To interpret pharmacokinetic (PK) data of biotherapeutics, it is critical to understand which drug species is being measured by the PK assay. For therapeutic antibodies, it is generally accepted that “free” circulating antibodies are the pharmacologically active form needed to determine the PK/ phar...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Landes Bioscience
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499303/ https://www.ncbi.nlm.nih.gov/pubmed/22820463 http://dx.doi.org/10.4161/mabs.20814 |