Pharmacokinetics of engineered human monomeric and dimeric CH2 domains

Therapeutic monoclonal antibodies have several advantages over small molecule drugs and small proteins and peptides, including a long serum half-life. The long serum half-life of IgG is due, in part, to its molecular weight (150kDa) and its ability to bind FcRn. Both the CH2 and CH3 domains of Fc ar...

Descripción completa

Detalles Bibliográficos
Autores principales: Gehlsen, Kurt R., Gong, Rui, Bramhill, Dave, Wiersma, David A., Kirkpatrick, Shaun A., Wang, Yangping, Feng, Yang, Dimitrov, Dimiter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2012
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499341/
https://www.ncbi.nlm.nih.gov/pubmed/22699277
http://dx.doi.org/10.4161/mabs.20652

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499341/
https://www.ncbi.nlm.nih.gov/pubmed/22699277
http://dx.doi.org/10.4161/mabs.20652

Ejemplares similares