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A Unified Method for Detecting Secondary Trait Associations with Rare Variants: Application to Sequence Data
Next-generation sequencing has made possible the detection of rare variant (RV) associations with quantitative traits (QT). Due to high sequencing cost, many studies can only sequence a modest number of selected samples with extreme QT. Therefore association testing in individual studies can be unde...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499373/ https://www.ncbi.nlm.nih.gov/pubmed/23166519 http://dx.doi.org/10.1371/journal.pgen.1003075 |