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Molecular mechanism of cytotoxicity induced by Hsp90-targeted Antp-TPR hybrid peptide in glioblastoma cells

BACKGROUND: Heat-shock protein 90 (Hsp90) is vital to cell survival under conditions of stress, and binds client proteins to assist in protein stabilization, translocation of polypeptides across cell membranes, and recovery of proteins from aggregates. Therefore, Hsp90 has emerged as an important ta...

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Detalles Bibliográficos
Autores principales: Horibe, Tomohisa, Torisawa, Aya, Kohno, Masayuki, Kawakami, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499401/
https://www.ncbi.nlm.nih.gov/pubmed/22913813
http://dx.doi.org/10.1186/1476-4598-11-59