Cargando…
The Human Cytomegalovirus DNA Polymerase Processivity Factor UL44 Is Modified by SUMO in a DNA-Dependent Manner
During the replication of human cytomegalovirus (HCMV) genome, the viral DNA polymerase subunit UL44 plays a key role, as by binding both DNA and the polymerase catalytic subunit it confers processivity to the holoenzyme. However, several lines of evidence suggest that UL44 might have additional rol...
Autores principales: | Sinigalia, Elisa, Alvisi, Gualtiero, Segré, Chiara V., Mercorelli, Beatrice, Muratore, Giulia, Winkler, Michael, Hsiao, He-Hsuan, Urlaub, Henning, Ripalti, Alessandro, Chiocca, Susanna, Palù, Giorgio, Loregian, Arianna |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499415/ https://www.ncbi.nlm.nih.gov/pubmed/23166733 http://dx.doi.org/10.1371/journal.pone.0049630 |
Ejemplares similares
-
Binding parameters and thermodynamics of the interaction of the human cytomegalovirus DNA polymerase accessory protein, UL44, with DNA: implications for the processivity mechanism
por: Loregian, Arianna, et al.
Publicado: (2007) -
Divide et impera: An In Silico Screening Targeting HCMV ppUL44 Processivity Factor Homodimerization Identifies Small Molecules Inhibiting Viral Replication
por: Ghassabian, Hanieh, et al.
Publicado: (2021) -
Regulated Transport into the Nucleus of Herpesviridae DNA Replication Core Proteins
por: Gualtiero, Alvisi, et al.
Publicado: (2013) -
Early inhibitors of human cytomegalovirus: State-of-art and therapeutic perspectives
por: Mercorelli, Beatrice, et al.
Publicado: (2011) -
The Dimeric Form of HPV16 E6 Is Crucial to Drive YAP/TAZ Upregulation through the Targeting of hScrib
por: Messa, Lorenzo, et al.
Publicado: (2021)