A Novel Interplay between Rap1 and PKA Regulates Induction of Angiogenesis in Prostate Cancer

Angiogenesis inhibition is an important therapeutic strategy for advanced stage prostate cancer. Previous work from our laboratory showed that sustained stimulation of Rap1 by 8-pCPT-2'-O-Me-cAMP (8CPT) via activation of Epac, a Rap1 GEF, or by expression of a constitutively active Rap1 mutant...

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Detalles Bibliográficos
Autores principales: Menon, Jyotsana, Doebele, Robert C., Gomes, Suzana, Bevilacqua, Elena, Reindl, Katie M., Rosner, Marsha Rich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499522/
https://www.ncbi.nlm.nih.gov/pubmed/23166790
http://dx.doi.org/10.1371/journal.pone.0049893

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499522/
https://www.ncbi.nlm.nih.gov/pubmed/23166790
http://dx.doi.org/10.1371/journal.pone.0049893

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