Plk1 is upregulated in androgen-insensitive prostate cancer cells and its inhibition leads to necroptosis

Castration-resistant prostate cancer (PCa) is refractory to hormone therapy and new strategies for treatment are urgently needed. We found that androgen-insensitive (AI) PCa cells, LNCaP-AI, are reprogrammed to upregulate the mitotic kinase Plk1 and other M phase cell cycle proteins, which may under...

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Detalles Bibliográficos
Autores principales: Deeraksa, Arpaporn, Pan, Jing, Sha, Youbao, Liu, Xian-De, Eissa, N Tony, Lin, Sue-Hwa, Yu-Lee, Li-yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499666/
https://www.ncbi.nlm.nih.gov/pubmed/22890325
http://dx.doi.org/10.1038/onc.2012.309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499666/
https://www.ncbi.nlm.nih.gov/pubmed/22890325
http://dx.doi.org/10.1038/onc.2012.309

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