Cargando…

Plk1 is upregulated in androgen-insensitive prostate cancer cells and its inhibition leads to necroptosis

Castration-resistant prostate cancer (PCa) is refractory to hormone therapy and new strategies for treatment are urgently needed. We found that androgen-insensitive (AI) PCa cells, LNCaP-AI, are reprogrammed to upregulate the mitotic kinase Plk1 and other M phase cell cycle proteins, which may under...

Descripción completa

Detalles Bibliográficos
Autores principales:	Deeraksa, Arpaporn, Pan, Jing, Sha, Youbao, Liu, Xian-De, Eissa, N Tony, Lin, Sue-Hwa, Yu-Lee, Li-yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499666/ https://www.ncbi.nlm.nih.gov/pubmed/22890325 http://dx.doi.org/10.1038/onc.2012.309

Ejemplares similares

Integrin Involvement in Freeze Resistance of Androgen-Insensitive Prostate Cancer
por: Baust, John G., et al.
Publicado: (2010)

A promoting role of androgen receptor in androgen-sensitive and -insensitive prostate cancer cells
por: Li, Tzu-Huey, et al.
Publicado: (2007)

Dynamic Phosphorylation of NudC by Aurora B in Cytokinesis
por: Weiderhold, Kimberly N., et al.
Publicado: (2016)

The challenges of androgen insensitivity syndrome
por: Ovidiu, Bratu, et al.
Publicado: (2021)

Embryonal carcinoma in androgen insensitivity syndrome
por: Barmon, Debabrata, et al.
Publicado: (2011)

Androgen insensitivity syndrome: a review
por: Batista, Rafael Loch, et al.
Publicado: (2018)

Refinement of the androgen response element based on ChIP-Seq in androgen-insensitive and androgen-responsive prostate cancer cell lines
por: Wilson, Stephen, et al.
Publicado: (2016)

PLK4 is upregulated in prostate cancer and its inhibition reduces centrosome amplification and causes senescence
por: Singh, Chandra K., et al.
Publicado: (2022)

Cotargeting Plk1 and androgen receptor enhances the therapeutic sensitivity of paclitaxel-resistant prostate cancer
por: Shin, Sol-Bi, et al.
Publicado: (2019)

Androgen Receptor Mutations Associated with Androgen Insensitivity Syndrome: A High Content Analysis Approach Leading to Personalized Medicine
por: Szafran, Adam T., et al.
Publicado: (2009)

ERBB2 Increases Metastatic Potentials Specifically in Androgen-Insensitive Prostate Cancer Cells
por: Tome-Garcia, Jessica, et al.
Publicado: (2014)

Exploiting TLK1 and Cisplatin Synergy for Synthetic Lethality in Androgen-Insensitive Prostate Cancer
por: Bhoir, Siddhant, et al.
Publicado: (2023)

Mutational Analysis of Androgen Receptor Gene in Two Families with Androgen Insensitivity
por: Akella, Radha Ramadevi
Publicado: (2017)

Complete Androgen Insensitivity Syndrome in Three Sisters
por: Verim, Levent
Publicado: (2014)

Partial Androgen Insensitivity Syndrome Presenting with Gynecomastia
por: Lee, Sung Won, et al.
Publicado: (2015)

An Early Case of Complete Androgen Insensitivity Syndrome
por: Matalka, Leen, et al.
Publicado: (2023)

A Novel Mutation of Androgen Receptor Gene in Complete Androgen Insensitivity Syndrome
por: Narumi, Satoshi, et al.
Publicado: (2007)

Androgen Receptor Gene Variants in New Cases of Equine Androgen Insensitivity Syndrome
por: Villagomez, Daniel A.F., et al.
Publicado: (2020)

Total glucosides of paeony inhibits lipopolysaccharide-induced proliferation, migration and invasion in androgen insensitive prostate cancer cells
por: Zhang, Zhi-Hui, et al.
Publicado: (2017)

Occurrence of testicular microlithiasis in androgen insensitive hypogonadal mice
por: O'Shaughnessy, Peter J, et al.
Publicado: (2009)

Genotype and phenotype of Vietnamese patients with androgen insensitivity syndrome
por: Dung, Vu Chi, et al.
Publicado: (2013)

Phenotypic and molecular characteristics of androgen insensitivity syndrome patients
por: Yuan, Shi-Min, et al.
Publicado: (2018)

SAT-213 Late Diagnosis of Complete Androgen Insensitivity
por: Tsai, Karen, et al.
Publicado: (2019)

Androgen Insensitivity Syndrome: A rare genetic disorder
por: Fulare, Sushrut, et al.
Publicado: (2020)

Complete Androgen Insensitivity Syndrome: From Bench to Bed
por: Tyutyusheva, Nina, et al.
Publicado: (2021)

Complete Androgen Insensitivity and Decreased Bone Mineral Density
por: Bauer, Elizabeth M, et al.
Publicado: (2021)

Bilateral Breast Phyllodes Tumor in Androgen Insensitivity Syndrome
por: Dutt, Aishwarya Sunil, et al.
Publicado: (2023)

Androgen receptor-mediated upregulation of quaking affects androgen receptor-related prostate cancer development and anti-androgen receptor therapy
por: Zhang, Keke, et al.
Publicado: (2018)

Epigenetics-related genes in prostate cancer: Expression profile in prostate cancer tissues, androgen-sensitive and -insensitive cell lines
por: ADLER, DAVID, et al.
Publicado: (2012)

Orphan nuclear receptor TLX contributes to androgen insensitivity in castration-resistant prostate cancer via its repression of androgen receptor transcription
por: Jia, Lin, et al.
Publicado: (2018)

Identification of the Rare Ala871Glu Mutation in the Androgen Receptor Gene Leading to Complete Androgen Insensitivity Syndrome in an Adolescent Girl with Primary Amenorrhea
por: Kapama, Aikaterini, et al.
Publicado: (2022)

Polyisoprenylated methylated protein methyl esterase as a putative drug target for androgen-insensitive prostate cancer
por: Poku, Rosemary A, et al.
Publicado: (2014)

Transient receptor potential melastatin 4 channel contributes to migration of androgen-insensitive prostate cancer cells
por: Holzmann, Christian, et al.
Publicado: (2015)

Chemopreventive Potential of Ethanolic Extracts of Luobuma Leaves (Apocynum venetum L.) in Androgen Insensitive Prostate Cancer
por: Huang, Szu-Ping, et al.
Publicado: (2017)

Comment on “Complete Androgen Insensitivity Syndrome: Optimizing Diagnosis and Management”
por: Balsamo, Antonio, et al.
Publicado: (2014)

Genetic analysis of a family with complete androgen insensitivity syndrome
por: Kota, Sunil Kumar, et al.
Publicado: (2013)

Laparoscopic gonedectomy in a case of complete androgen insensitivity syndrome
por: Bhaskararao, G., et al.
Publicado: (2014)

Minor Hypospadias: The “Tip of the Iceberg” of the Partial Androgen Insensitivity Syndrome
por: Kalfa, Nicolas, et al.
Publicado: (2013)

Potential risk of inguinal hernia in complete androgen insensitivity syndrome
por: Kimizuka, Yu, et al.
Publicado: (2022)

Induction of lactation in a patient with complete androgen insensitivity syndrome
por: Voon, Kimberly, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_9124beve3vdaa58i5b3s2kcdmp