Structure Activity Relationships of α-L-LNA Modified Phosphorothioate Gapmer Antisense Oligonucleotides in Animals

We report the structure activity relationships of short 14-mer phosphorothioate gapmer antisense oligonucleotides (ASOs) modified with α-L-locked nucleic acid (LNA) and related modifications targeting phosphatase and tensin homologue (PTEN) messenger RNA in mice. α-L-LNA represents the α-anomer of e...

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Detalles Bibliográficos
Autores principales: Seth, Punit P, Jazayeri, Ali, Yu, Jeff, Allerson, Charles R, Bhat, Balkrishen, Swayze, Eric E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499693/
https://www.ncbi.nlm.nih.gov/pubmed/23344239
http://dx.doi.org/10.1038/mtna.2012.34

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499693/
https://www.ncbi.nlm.nih.gov/pubmed/23344239
http://dx.doi.org/10.1038/mtna.2012.34

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