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Structure Activity Relationships of α-L-LNA Modified Phosphorothioate Gapmer Antisense Oligonucleotides in Animals
We report the structure activity relationships of short 14-mer phosphorothioate gapmer antisense oligonucleotides (ASOs) modified with α-L-locked nucleic acid (LNA) and related modifications targeting phosphatase and tensin homologue (PTEN) messenger RNA in mice. α-L-LNA represents the α-anomer of e...
Autores principales: | Seth, Punit P, Jazayeri, Ali, Yu, Jeff, Allerson, Charles R, Bhat, Balkrishen, Swayze, Eric E |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499693/ https://www.ncbi.nlm.nih.gov/pubmed/23344239 http://dx.doi.org/10.1038/mtna.2012.34 |
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