Epigenetic Modification of the Repair Donor Regulates Targeted Gene Correction

Optimizing design of vectors is critical to effective gene therapy. In targeted gene correction (TGC), cleavage of chromosomal DNA near a mutation stimulates homology-directed repair of a target gene using a donor provided in trans. We have systematically addressed epigenetic parameters of donor des...

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Detalles Bibliográficos
Autores principales: Humbert, Olivier, Maizels, Nancy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499697/
https://www.ncbi.nlm.nih.gov/pubmed/23344649
http://dx.doi.org/10.1038/mtna.2012.42

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499697/
https://www.ncbi.nlm.nih.gov/pubmed/23344649
http://dx.doi.org/10.1038/mtna.2012.42

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