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The role of CTCF binding sites in the 3′ immunoglobulin heavy chain regulatory region
The immunoglobulin heavy chain locus undergoes a series of DNA rearrangements and modifications to achieve the construction and expression of individual antibody heavy chain genes in B cells. These events affect variable regions, through VDJ joining and subsequent somatic hypermutation, and constant...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499808/ https://www.ncbi.nlm.nih.gov/pubmed/23162572 http://dx.doi.org/10.3389/fgene.2012.00251 |