Human Leukocyte Antigen (HLA) Class I Down-Regulation by Human Immunodeficiency Virus Type 1 Negative Factor (HIV-1 Nef): What Might We Learn From Natural Sequence Variants?

HIV-1 causes a chronic infection in humans that is characterized by high plasma viremia, progressive loss of CD4+ T lymphocytes, and severe immunodeficiency resulting in opportunistic disease and AIDS. Viral persistence is mediated in part by the ability of the Nef protein to down-regulate HLA molec...

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Detalles Bibliográficos
Autores principales: Mwimanzi, Philip, Markle, Tristan J., Ueno, Takamasa, Brockman, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499827/
https://www.ncbi.nlm.nih.gov/pubmed/23170180
http://dx.doi.org/10.3390/v4091711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499827/
https://www.ncbi.nlm.nih.gov/pubmed/23170180
http://dx.doi.org/10.3390/v4091711

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