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Disseminated Breast Cancer Cells Acquire a Highly Malignant and Aggressive Metastatic Phenotype during Metastatic Latency in the Bone

BACKGROUND: Disseminated tumor cells (DTCs) in the bone marrow may exist in a dormant state for extended periods of time, maintaining the ability to proliferate upon activation, engraft at new sites, and form detectable metastases. However, understanding of the behavior and biology of dormant breast...

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Detalles Bibliográficos
Autores principales: Marsden, Carolyn G., Wright, Mary Jo, Carrier, Latonya, Moroz, Krzysztof, Rowan, Brian G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500091/
https://www.ncbi.nlm.nih.gov/pubmed/23173031
http://dx.doi.org/10.1371/journal.pone.0047587