Deletion of CDKAL1 Affects High-Fat Diet–Induced Fat Accumulation and Glucose-Stimulated Insulin Secretion in Mice, Indicating Relevance to Diabetes

BACKGROUND/OBJECTIVE: The CDKAL1 gene is among the best-replicated susceptibility loci for type 2 diabetes, originally identified by genome-wide association studies in humans. To clarify a physiological importance of CDKAL1, we examined effects of a global Cdkal1-null mutation in mice and also evalu...

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Detalles Bibliográficos
Autores principales: Okamura, Tadashi, Yanobu-Takanashi, Rieko, Takeuchi, Fumihiko, Isono, Masato, Akiyama, Koichi, Shimizu, Yukiko, Goto, Motohito, Liang, Yi-Qiang, Yamamoto, Ken, Katsuya, Tomohiro, Fujioka, Akihiro, Ohnaka, Keizo, Takayanagi, Ryoichi, Ogihara, Toshio, Yamori, Yukio, Kato, Norihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500257/
https://www.ncbi.nlm.nih.gov/pubmed/23173044
http://dx.doi.org/10.1371/journal.pone.0049055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500257/
https://www.ncbi.nlm.nih.gov/pubmed/23173044
http://dx.doi.org/10.1371/journal.pone.0049055

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