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Genetic Characterization of smg-8 Mutants Reveals No Role in C. elegans Nonsense Mediated Decay
The nonsense mediated decay (NMD) pathway degrades mRNAs bearing premature translation termination codons. In mammals, SMG-8 has been implicated in the NMD pathway, in part by its association with SMG-1 kinase. Here we use four independent assays to show that C. elegans smg-8 is not required to degr...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2012
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500306/ https://www.ncbi.nlm.nih.gov/pubmed/23166684 http://dx.doi.org/10.1371/journal.pone.0049490 |