Phosphorylation of ΔNp63α via a Novel TGFβ/ALK5 Signaling Mechanism Mediates the Anti-Clonogenic Effects of TGFβ

Genetic analysis of TP63 implicates ΔNp63 isoforms in preservation of replicative capacity and cellular lifespan within adult stem cells. ΔNp63α is also an oncogene and survival factor that mediates therapeutic resistance in squamous carcinomas. These diverse activities are the result of genetic and...

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Detalles Bibliográficos
Autores principales: Cherukuri, Pratima, DeCastro, Andrew J., Balboni, Amanda L., Downey, Sondra L., Liu, Jennifer Y., Hutchinson, Justine A., DiRenzo, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500343/
https://www.ncbi.nlm.nih.gov/pubmed/23166821
http://dx.doi.org/10.1371/journal.pone.0050066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500343/
https://www.ncbi.nlm.nih.gov/pubmed/23166821
http://dx.doi.org/10.1371/journal.pone.0050066

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