Antagonistic and Cooperative Actions of Kif7 and Sufu Define Graded Intracellular Gli Activities in Hedgehog Signaling

Graded Hedgehog (Hh) signaling governs the balance of Gli transcriptional activators and repressors to specify diverse ventral cell fates in the spinal cord. It remains unclear how distinct intracellular Gli activity is generated. Here, we demonstrate that Sufu acts universally as a negative regulat...

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Detalles Bibliográficos
Autores principales: Law, Kelvin King Lo, Makino, Shigeru, Mo, Rong, Zhang, Xiaoyun, Puviindran, Vijitha, Hui, Chi-chung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500354/
https://www.ncbi.nlm.nih.gov/pubmed/23166838
http://dx.doi.org/10.1371/journal.pone.0050193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500354/
https://www.ncbi.nlm.nih.gov/pubmed/23166838
http://dx.doi.org/10.1371/journal.pone.0050193

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