Sensitivity to Lysosome-Dependent Cell Death Is Directly Regulated by Lysosomal Cholesterol Content

Alterations in lipid homeostasis are implicated in several neurodegenerative diseases, although the mechanisms responsible are poorly understood. We evaluated the impact of cholesterol accumulation, induced by U18666A, quinacrine or mutations in the cholesterol transporting Niemann-Pick disease type...

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Detalles Bibliográficos
Autores principales: Appelqvist, Hanna, Sandin, Linnea, Björnström, Karin, Saftig, Paul, Garner, Brett, Öllinger, Karin, Kågedal, Katarina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500374/
https://www.ncbi.nlm.nih.gov/pubmed/23166840
http://dx.doi.org/10.1371/journal.pone.0050262

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500374/
https://www.ncbi.nlm.nih.gov/pubmed/23166840
http://dx.doi.org/10.1371/journal.pone.0050262

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