Drosophila insulin-like peptide-6 (dilp6) expression from fat body extends lifespan and represses secretion of Drosophila insulin-like peptide-2 from the brain

Reduced insulin/IGF signaling extends lifespan in diverse species, including Drosophila melanogaster where the genome encodes seven insulin-like peptides (dilp1-7). Of these, reduced dilp2 expressed in the brain has been associated with longevity assurance when over-expression of dfoxo in fat bodies...

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Detalles Bibliográficos
Autores principales: Bai, Hua, Kang, Ping, Tatar, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2012
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500397/
https://www.ncbi.nlm.nih.gov/pubmed/22935001
http://dx.doi.org/10.1111/acel.12000

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500397/
https://www.ncbi.nlm.nih.gov/pubmed/22935001
http://dx.doi.org/10.1111/acel.12000

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