Cargando…

Endothelial cell dysfunction and cytoskeletal changes associated with repression of p16(INK4a) during immortalization

The immortalization process is a fundamental step in the development of most (if not all) human cancers, including the aggressive endothelial cell (EC)-derived malignancy angiosarcoma. Inactivation of the tumor suppressor p16(INK4a) and the development of multiple chromosomal abnormalities are featu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kan, C-Y, Wen, V W, Pasquier, E, Jankowski, K, Chang, M, Richards, L A, Kavallaris, M, MacKenzie, K L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500701/ https://www.ncbi.nlm.nih.gov/pubmed/22310292 http://dx.doi.org/10.1038/onc.2011.645

Ejemplares similares

Concentration- and schedule-dependent effects of chemotherapy on the angiogenic potential and drug sensitivity of vascular endothelial cells
por: Pasquier, Eddy, et al.
Publicado: (2012)

Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression
por: Soo, Julia K, et al.
Publicado: (2011)

p16(INK4A) Represses the paracrine tumor-promoting effects of breast stromal fibroblasts
por: Al-Ansari, M M, et al.
Publicado: (2013)

p16(INK4A) Represses the paracrine tumor-promoting effects of breast stromal fibroblasts
por: Al-Ansari, M M, et al.
Publicado: (2013)

Extremely stringent activation of p16(INK4a) prevents immortalization of uterine cervical epithelial cells without human papillomavirus oncogene expression
por: Hang, Su, et al.
Publicado: (2016)

MOZ-Mediated Repression of p16(INK)(4)(a) Is Critical for the Self-Renewal of Neural and Hematopoietic Stem Cells
por: Perez-Campo, Flor M, et al.
Publicado: (2014)

CtBP1 is expressed in melanoma and represses the transcription of p16INK4a and Brca1
por: Deng, Hui, et al.
Publicado: (2013)

p16(INK4a) Prevents Centrosome Dysfunction and Genomic Instability in Primary Cells
por: McDermott, Kimberly M, et al.
Publicado: (2006)

The transcription factor Slug represses p16(Ink4a) and regulates murine muscle stem cell aging
por: Zhu, Pei, et al.
Publicado: (2019)

Cigarette Smoke Extract Changes Expression of Endothelial Nitric Oxide Synthase (eNOS) and p16(INK4a) and is Related to Endothelial Progenitor Cell Dysfunction
por: He, Zhihui, et al.
Publicado: (2017)

Cytoskeletal Remodeling Mimics Endothelial Response to Microgravity
por: Locatelli, Laura, et al.
Publicado: (2021)

Therapeutic targeting of replicative immortality
por: Yaswen, Paul, et al.
Publicado: (2015)

Established Immortalized Cavernous Endothelial Cells Improve Erectile Dysfunction in Rats with Cavernous Nerve Injury
por: Bak, Sang Hong, et al.
Publicado: (2023)

In Vitro Endothelialization Test of Biomaterials Using Immortalized Endothelial Cells
por: Kono, Ken, et al.
Publicado: (2016)

Immortalization of mouse myogenic cells can occur without loss of p16(INK4a), p19(ARF), or p53 and is accelerated by inactivation of Bax
por: Nowak, Jonathan A, et al.
Publicado: (2004)

Senescence delay and repression of p16(INK4a) by Lsh via recruitment of histone deacetylases in human diploid fibroblasts
por: Zhou, Rui, et al.
Publicado: (2009)

Induction of p16 during immortalization by HPV 16 and 18 and not during malignant transformation.
por: Nakao, Y., et al.
Publicado: (1997)

Somatic p16(INK4a) loss accelerates melanomagenesis
por: Monahan, K B, et al.
Publicado: (2010)

The cytoskeletal mechanisms of cell–cell junction formation in endothelial cells
por: Hoelzle, Matthew K., et al.
Publicado: (2012)

γ-Actin plays a key role in endothelial cell motility and neovessel maintenance
por: Pasquier, Eddy, et al.
Publicado: (2015)

Adiponectin Prevents Diabetic Premature Senescence of Endothelial Progenitor Cells and Promotes Endothelial Repair by Suppressing the p38 MAP Kinase/p16(INK4A) Signaling Pathway
por: Chang, Junlei, et al.
Publicado: (2010)

Loss of p16(Ink4a) Function Rescues Cellular Senescence Induced by Telomere Dysfunction
por: Zhang, Xiufeng, et al.
Publicado: (2012)

Epigenetic repression of ribosomal RNA transcription by ROCK-dependent aberrant cytoskeletal organization
por: Wu, Tse-Hsiang, et al.
Publicado: (2016)

Development of immortalized mouse aortic endothelial cell lines
por: Ni, Chih-Wen, et al.
Publicado: (2014)

Spontaneous immortalization of mouse liver sinusoidal endothelial cells
por: ZHAO, XIUHUA, et al.
Publicado: (2015)

Modeling human endothelial cell transformation in vascular neoplasias
por: Wen, Victoria W., et al.
Publicado: (2013)

Quercetin reduces hydroxyurea induced cytotoxicity in immortalized mouse aortic endothelial cells
por: Kiser, Zachary M., et al.
Publicado: (2017)

p16INK4a in cellular senescence
por: Simboeck, Elisabeth, et al.
Publicado: (2013)

p16(INK4a) Expression in Porokeratosis
por: Uryu, Miki, et al.
Publicado: (2017)

Effective Management of Advanced Angiosarcoma by the Synergistic Combination of Propranolol and Vinblastine-based Metronomic Chemotherapy: A Bench to Bedside Study
por: Pasquier, Eddy, et al.
Publicado: (2016)

CDK6 Degradation Is Counteracted by p16(INK4A) and p18(INK4C) in AML
por: Schmalzbauer, Belinda S., et al.
Publicado: (2022)

The effects of transferring tumor suppressor gene p16(INK4A) to p16(INK4A)-deleted cancer cells*
por: Lee, Kye Young, et al.
Publicado: (1999)

Dextran-Catechin inhibits angiogenesis by disrupting copper homeostasis in endothelial cells
por: Yee, Eugene M. H., et al.
Publicado: (2017)

Autophagy regulates the localization and degradation of p16(INK4a)
por: Coryell, Philip R., et al.
Publicado: (2020)

A Review of the Current Impact of Inhibitors of Apoptosis Proteins and Their Repression in Cancer
por: Cetraro, Pierina, et al.
Publicado: (2022)

Metrics for Assessing Cytoskeletal Orientational Correlations and Consistency
por: Drew, Nancy K., et al.
Publicado: (2015)

Reply: Comment on ‘Beta-blockers increase response to chemotherapy via direct anti-tumour and anti-angiogenic mechanisms in neuroblastoma' – β-blockers are potent anti-angiogenic and chemo-sensitising agents, rather than cytotoxic drugs
por: Pasquier, E, et al.
Publicado: (2013)

Aerobic exercise induces tumor suppressor p16(INK4a) expression of endothelial progenitor cells in human skeletal muscle
por: Wu, Jinfu, et al.
Publicado: (2020)

p16(INK4a)-induced senescence is disabled by melanoma-associated mutations
por: Haferkamp, Sebastian, et al.
Publicado: (2008)

Endothelial Dysfunction in Pregnancy Complications
por: Kornacki, Jakub, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_u9f0n4sjhgmmkmlaodsv674vro