Nucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress

Nucleotide deficiency causes replication stress (RS) and DNA damage in dividing cells. How nucleotide metabolism is regulated in vivo to prevent these deleterious effects remains unknown. In this study, we investigate a functional link between nucleotide deficiency, RS, and the nucleoside salvage pa...

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Detalles Bibliográficos
Autores principales: Austin, Wayne R., Armijo, Amanda L., Campbell, Dean O., Singh, Arun S., Hsieh, Terry, Nathanson, David, Herschman, Harvey R., Phelps, Michael E., Witte, Owen N., Czernin, Johannes, Radu, Caius G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501349/
https://www.ncbi.nlm.nih.gov/pubmed/23148236
http://dx.doi.org/10.1084/jem.20121061

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501349/
https://www.ncbi.nlm.nih.gov/pubmed/23148236
http://dx.doi.org/10.1084/jem.20121061

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