Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis

The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for Alzheimer’s disease (AD). The influence of apoE on amyloid β (Aβ) accumulation may be the major mechanism by which apoE affects AD. ApoE interacts with Aβ and facilitates Aβ fibrillogenesis in vitro. In addition, apoE is...

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Detalles Bibliográficos
Autores principales: Kim, Jungsu, Eltorai, Adam E.M., Jiang, Hong, Liao, Fan, Verghese, Philip B., Kim, Jaekwang, Stewart, Floy R., Basak, Jacob M., Holtzman, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501350/
https://www.ncbi.nlm.nih.gov/pubmed/23129750
http://dx.doi.org/10.1084/jem.20121274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501350/
https://www.ncbi.nlm.nih.gov/pubmed/23129750
http://dx.doi.org/10.1084/jem.20121274

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