Complement factor C5a and C5a receptor contribute to morphine tolerance and withdrawal-induced hyperalgesia in rats

Morphine is a potent opioid analgesic. However, the repeated use of morphine causes tolerance and hyperalgesia. Neuroinflammation has been reported to be involved in morphine tolerance and withdrawal-induced hyperalgesia. The complement system is a crucial effector mechanism of immune responses. The...

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Detalles Bibliográficos
Autores principales: LI, YAN-HUA, JIN, HUA, XU, JING-SHU, GUO, GUANG-QIONG, CHEN, DA-LIN, BO, YUN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2012
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501444/
https://www.ncbi.nlm.nih.gov/pubmed/23170133
http://dx.doi.org/10.3892/etm.2012.636

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501444/
https://www.ncbi.nlm.nih.gov/pubmed/23170133
http://dx.doi.org/10.3892/etm.2012.636

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