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A Metal-Based Inhibitor of NEDD8-Activating Enzyme
A cyclometallated rhodium(III) complex [Rh(ppy)(2)(dppz)](+) (1) (where ppy = 2-phenylpyridine and dppz = dipyrido[3,2-a:2′,3′-c]phenazine dipyridophenazine) has been prepared and identified as an inhibitor of NEDD8-activating enzyme (NAE). The complex inhibited NAE activity in cell-free and cell-ba...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501507/ https://www.ncbi.nlm.nih.gov/pubmed/23185368 http://dx.doi.org/10.1371/journal.pone.0049574 |