The Ubiquitin Ligase TRAF6 Negatively Regulates the JAK-STAT Signaling Pathway by Binding to STAT3 and Mediating Its Ubiquitination

STAT3 is a key transcription factor that mediates various cellular and organismal processes, such as cell growth, apoptosis, immune response and cancer. However, the molecular mechanisms of STAT3 regulation remain poorly understood. Here, we identified TRAF6 as a new STAT3 interactor. TRAF6 augmente...

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Detalles Bibliográficos
Autores principales: Wei, Juncheng, Yuan, Yanzhi, Jin, Chaozhi, Chen, Hui, Leng, Ling, He, Fuchu, Wang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501508/
https://www.ncbi.nlm.nih.gov/pubmed/23185365
http://dx.doi.org/10.1371/journal.pone.0049567

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501508/
https://www.ncbi.nlm.nih.gov/pubmed/23185365
http://dx.doi.org/10.1371/journal.pone.0049567

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