Altered APP Processing in Insulin-Resistant Conditions Is Mediated by Autophagosome Accumulation via the Inhibition of Mammalian Target of Rapamycin Pathway

Insulin resistance, one of the major components of type 2 diabetes mellitus (T2DM), is a known risk factor for Alzheimer’s disease (AD), which is characterized by an abnormal accumulation of intra- and extracellular amyloid β peptide (Aβ). Insulin resistance is known to increase Aβ generation, but t...

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Detalles Bibliográficos
Autores principales: Son, Sung Min, Song, Hyundong, Byun, Jayoung, Park, Kyong Soo, Jang, Hak Chul, Park, Young Joo, Mook-Jung, Inhee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2012
Materias:
Metabolism
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501871/
https://www.ncbi.nlm.nih.gov/pubmed/22829447
http://dx.doi.org/10.2337/db11-1735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501871/
https://www.ncbi.nlm.nih.gov/pubmed/22829447
http://dx.doi.org/10.2337/db11-1735

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