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Altered APP Processing in Insulin-Resistant Conditions Is Mediated by Autophagosome Accumulation via the Inhibition of Mammalian Target of Rapamycin Pathway

Insulin resistance, one of the major components of type 2 diabetes mellitus (T2DM), is a known risk factor for Alzheimer’s disease (AD), which is characterized by an abnormal accumulation of intra- and extracellular amyloid β peptide (Aβ). Insulin resistance is known to increase Aβ generation, but t...

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Detalles Bibliográficos
Autores principales:	Son, Sung Min, Song, Hyundong, Byun, Jayoung, Park, Kyong Soo, Jang, Hak Chul, Park, Young Joo, Mook-Jung, Inhee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2012
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501871/ https://www.ncbi.nlm.nih.gov/pubmed/22829447 http://dx.doi.org/10.2337/db11-1735

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