PEGylation Extends Circulation Half-Life While Preserving In Vitro and In Vivo Activity of Tissue Inhibitor of Metalloproteinases-1 (TIMP-1)

Excess proteolytic activity of matrix metalloproteinases (MMPs) contributes to the development of arthritis, cardiovascular diseases and cancer progression, implicating these enzymes as therapeutic targets. While many small molecule inhibitors of MMPs have been developed, clinical uses have been lim...

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Detalles Bibliográficos
Autores principales: Batra, Jyotica, Robinson, Jessica, Mehner, Christine, Hockla, Alexandra, Miller, Erin, Radisky, Derek C., Radisky, Evette S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502186/
https://www.ncbi.nlm.nih.gov/pubmed/23185522
http://dx.doi.org/10.1371/journal.pone.0050028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502186/
https://www.ncbi.nlm.nih.gov/pubmed/23185522
http://dx.doi.org/10.1371/journal.pone.0050028

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